A new U.S. attack on Iran could risk large-scale retaliation

WASHINGTON — Although weakened and facing a domestic crisis, Iran’s regime still has substantial firepower that could inflict damage on American interests and allies in the region, disrupt the global economy and trigger a protracted conflict in response to a U.S. military attack, according to former U.S. officials, foreign diplomats and regional analysts ANALYSISNational SecurityNational SecurityA new U.S. attack on Iran could risk large-scale retaliationIf Iran’s leaders believe U.S. strikes threaten their hold on power, they may opt to launch large-scale retaliation aimed at causing American casualties or disrupting the oil industry in the Persian Gulf, former U.S. officials, foreign diplomats and experts say.Iranian President Masoud Pezeshkian at a meeting with provincial governors in Tehran on Jan. 27. Iranian Presidency Handout / Anadolu / Getty ImagesShareAdd NBC News to GoogleFeb. 23, 2026, 9:00 PM ESTBy Dan De Luce, Gordon Lubold, Natasha Lebedeva and Keir SimmonsListen to this article with a free account00:0000:00WASHINGTON — Although weakened and facing a domestic crisis, Iran’s regime still has substantial firepower that could inflict damage on American interests and allies in the region, disrupt the global economy and trigger a protracted conflict in response to a U.S. military attack, according to former U.S. officials, foreign diplomats and regional analysts.The prospect of Iranian retaliation has factored into President Donald Trump’s deliberations over whether to order a military attack in Iran following strikes on its nuclear program in June, as well as discussions between the U.S. and its allies in the Middle East, according to current U.S. officials.While Iran retaliated in June against Israel and a U.S. base in Qatar, it stopped short of more dramatic actions that could have caused casualties among American forces or destabilized Persian Gulf economies. Iran’s response to U.S. military action could play out very differently this time if Trump makes that decision, the former officials, diplomats and analysts said, particularly if Iranian leaders perceive a threat to their survival.“What could be different this time is that they do try to regionalize this, as opposed to just going after Israel or going after U.S. bases,” said Joseph Votel, a retired four-star Army general who oversaw U.S. forces in the Middle East in Trump’s first term.Votel, now a senior fellow with the Middle East Institute, a think tank, said one possibility is that Iran would try to target oil refineries in the Persian Gulf states in a bid “to drag everybody into this and turn this into a much more protracted conflict.”The U.S. and Iran are expected to hold another round of diplomatic talks as soon as Thursday, according to administration officials. Administration officials have indicated that Iran must make major concessions on its nuclear program, including abandoning uranium enrichment, to avert possible U.S. military action.Trump’s Middle East envoy, Steve Witkoff, who is leading the Iran talks along with Trump’s son-in-law Jared Kushner, said over the weekend that “there were red lines: zero enrichment, we have to have the material back.”Asked in a Fox News interview why Iran isn’t cutting a deal with the U.S. under such intense military and economic pressure, Witkoff said Trump has asked him the same question. “He’s curious as to why they haven’t, I don’t want to use the word ‘capitulated,’ but why they haven’t capitulated,” Witkoff said.Trump is considering a range of military options if diplomatic efforts fail — from limited strikes targeting nuclear and missile sites to a wider assault designed to weaken or even topple the regime, NBC News has reported.But what Trump views as “limited” may not be interpreted that way by Iran, particularly if Iranian leaders believe the regime’s survival is at stake, according to former U.S. officials, foreign diplomats and regional analysts.“If they see this as an existential threat ... their reaction will certainly be disproportionate,” a Middle Eastern diplomat said of Iran's leaders.Iran has suffered debilitating setbacks over the past year with the fall of the Assad regime in neighboring Syria, the devastation of its Hezbollah proxies in Lebanon and the U.S. and Israeli bombing of its nuclear and missile programs in June.But Tehran still has a significant supply of ballistic missiles, cruise missiles and drones, and it could try to retaliate with strikes across the Persian Gulf in a bid to sow economic instability and cause alarm among U.S. allies such as Saudi Arabia, Qatar and the United Arab Emirates.Iran could calibrate its response depending on the scale of the U.S. attack and ratchet up its actions if leaders perceive an attempt by the U.S. to topple the regime, said Joseph Costa of the Atlantic Council, a Washington, D.C.-based think tank. “Iran might calculate it must increase the costs of war,” said Costa, who helped oversee war planning as a senior official at the Defense Department during the Biden administration.Last month, some Arab state leaders privately expressed concern to administration officials about Trump’s striking Iran at the time because they weren’t confident their countries were prepared to respond to any Iranian retaliation, NBC News reported. In recent days, however, those leaders have been reas